Key result
ILK gene therapy improved cardiac remodeling and function in rats after myocardial infarction, reducing infarct scar size and LV end-systolic diameter at 9 weeks.
Why the study?
Does integrin-linked kinase (ILK) gene therapy improve cardiac remodeling and function in rats after myocardial infarction?
Does integrin-linked kinase (ILK) gene therapy improve cardiac remodeling and function in rats after myocardial infarction?
ILK gene therapy attenuates left ventricular remodeling and improves cardiac function in a rat model of myocardial infarction, highlighting a potential new approach for post-infarct heart failure.
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Hypothesis-generating for ILK gene therapy post-MI; leaves open translation to human remodeling and clinical use.
Ding et al. (2009) studied Myocardial infarction (n=50). Adenoviral vector expressing ILK (adeno-ILK) vs. Empty adeno-null vector was evaluated on Cardiac remodeling and function. ILK gene therapy improved cardiac remodeling and function in rats after myocardial infarction, reducing infarct scar size and LV end-systolic diameter at 9 weeks.
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