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December 19, 1990JAMA

Beneficial effects of colestipol-niacin on coronary atherosclerosis. A 4-year follow-up

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Why the study?

Does combined colestipol-niacin therapy improve angiographic outcomes (nonprogression and regression of coronary atherosclerosis) in coronary bypass subjects?

Population

103 subjects (subgroup of original 162 subjects) with prior coronary bypass

Comparison

Combined colestipol-niacin therapy for 4 years vs Placebo

Design

RCT, randomized, placebo-controlled

Follow-up

4 years

Authors

LCLinda Cashin-HemphillUniversity of Southern California

Discussion

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Implication

Supports lipid-lowering for lesion regression in bypass patients; confirms angiographic benefits in long-term secondary prevention.

Structured PICO

Does combined colestipol-niacin therapy improve angiographic outcomes (nonprogression and regression of coronary atherosclerosis) in coronary bypass subjects?

P
Population
103 subjects (subgroup of original 162 subjects) with prior coronary bypass
I
Intervention
Combined colestipol-niacin therapy for 4 years
C
Comparator
Placebo
O
Outcome
Nonprogression and regression in native coronary artery lesions assessed angiographically at 4 yearssurrogate

Long-term (4-year) lipid-lowering therapy with colestipol-niacin significantly reduces progression and increases regression of coronary atherosclerosis in post-bypass patients.

Cite This Study

Linda Cashin-Hemphill (1990) studied this question.

synapsesocial.com/papers/6a98ca122d0bc910e975b3d7https://doi.org/10.1001/jama.264.23.3013
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Beneficial effects of combined colestipol-niacin therapy on coronary atherosclerosis and coronary venous bypass grafts1987 · 218 citations
  2. 2Beneficial Effects of Combined Colestipol-Niacin Therapy on Coronary Atherosclerosis and Coronary Venous Bypass Grafts1987 · 1,625 citations
  3. 3Effects of colestipol-niacin therapy on human femoral atherosclerosis.1991 · 174 citations
  4. 4One-year reduction and longitudinal analysis of carotid intima-media thickness associated with colestipol/niacin therapy.1993 · 128 citations
  5. 5Beneficial effects of colestipol-niacin therapy on the common carotid artery. Two- and four-year reduction of intima-media thickness measured by ultrasound.1993 · 386 citations