Key result
Pregnancy in women with repaired Tetralogy of Fallot was associated with a significant increase in the Tei index during the second and third trimesters compared to healthy pregnant controls (p=0.026), indicating subclinical left ventricular intolerance to volume overload.
Why the study?
Does pregnancy alter left ventricular performance measured by the Tei index in women with repaired tetralogy of Fallot compared to normal pregnant women?
Population
72 women, including 11 women with repaired tetralogy of Fallot, 20 age-matched non-pregnant women, and 41…
Comparison
Pregnancy (prospective observational evaluation) vs Normal pregnant women without heart disease and…
Design
Cohort
Follow-up
Throughout pregnancy and 5-14 days after delivery
Authors
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May support closer echocardiographic surveillance in pregnancy; hypothesis-generating for Tei index utility in repaired TOF.
Observational (n=72)
No
Does pregnancy alter left ventricular performance measured by the Tei index in women with repaired tetralogy of Fallot compared to normal pregnant women?
p-value: p=0.026
Pregnant women with repaired tetralogy of Fallot exhibit subclinical left ventricular intolerance to volume overload during the second and third trimesters, as evidenced by an increased Tei index and smaller LVEDD.
Hidaka et al. (2003) conducted an observational in Repaired Tetralogy of Fallot during pregnancy (n=72). Pregnancy with repaired Tetralogy of Fallot vs. Healthy pregnant and non-pregnant women was evaluated on Change in left ventricular Tei index during pregnancy (p=0.026). Pregnancy in women with repaired Tetralogy of Fallot was associated with a significant increase in the Tei index during the second and third trimesters compared to healthy pregnant controls (p=0.026), indicating subclinical left ventricular intolerance to volume overload.
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