Key result
The left atrial endocardium demonstrated a 50% lower ability to activate protein C and lower thrombomodulin expression compared to the right atrium (52.5 vs 72.1 arbitrary units; P=0.028).
Absolute Event Rate: 52.5% vs 72.1%
p-value: p=0.028
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Suggests greater left atrial thrombogenicity; hypothesis-generating for thrombomodulin-targeted strategies in AF, pending clinical validation.
Cerveró et al. (2011) studied Atrial fibrillation / Cardioembolic stroke (n=6). Left atrial endocardium vs. Right atrial endocardium was evaluated on Thrombomodulin expression (arbitrary intensity units) (p=0.028). The left atrial endocardium demonstrated a 50% lower ability to activate protein C and lower thrombomodulin expression compared to the right atrium (52.5 vs 72.1 arbitrary units; P=0.028).
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