Key result
Coronary artery disease patients exhibited a smaller decrease in repeated forearm hyperaemic reactivity compared to low-risk participants (2.9 to 2.6 vs 5.2 to 3.6; interaction P<0.005).
Why the study?
Does short-term repeated reactive hyperaemia testing show differential exhaustion of vascular reactivity in CAD patients compared to healthy low-risk participants?
Observational (n=34)
Does short-term repeated reactive hyperaemia testing show differential exhaustion of vascular reactivity in CAD patients compared to healthy low-risk participants?
Short-term repeated hyperaemic reactivity testing reveals significant exhaustion in healthy individuals but not in CAD patients, highlighting the need to account for disease state in repeated measure studies.
Repeated hyperaemic testing may show less reactivity exhaustion in CAD; hypothesis-generating for disease-state adjustment in vascular studies.
The hyperaemic response of the forearm is a widely used technique to assess the vascular reactivity. Little is known about the short-term reproducibility and the possible exhaustion of this response in normal or diseased states. As such, the current study was conducted to assess this phenomenon using a unique nuclear medicine- (NM-) based technique. 19 patients with coronary artery disease (CAD) undergoing NM exercise stress tests and 15 low risk (LR) participants completed 2 reactive hyperaemia tests, using a SPECT-based technique, separated by 15 min. Analyses revealed that CAD patients had lower hyperaemic responses than LR participants (P < .001), and that there was a significant group × time interaction (P < .005), such that LR participants showed a larger decrease in the reactivity (5.2 ± 0.4 to 3.6 ± 0.4) than the CAD patients (2.9 ± 0.3 to 2.6 ± 0.3). These results suggest that there is a variability, due to disease states, in the reproducibility of the hypaeremic reactivity. This needs to be taken into account in short-term repeated measure studies.
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Bacon et al. (2012) conducted an observational in Coronary artery disease (n=34). Coronary artery disease vs. Low risk participants was evaluated on Short-term repeated forearm hyperaemic reactivity (p=< .005). Coronary artery disease patients exhibited a smaller decrease in repeated forearm hyperaemic reactivity compared to low-risk participants (2.9 to 2.6 vs 5.2 to 3.6; interaction P<0.005).
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