Key result
The highest tertile of full-length betatrophin levels was associated with significantly higher odds of having metabolic syndrome (OR 8.6; 95% CI 2.8-26.8; P<0.001).
Why the study?
Are circulating betatrophin levels increased in patients with drug-naïve metabolic syndrome compared to healthy controls?
Case-Control (n=94)
Are circulating betatrophin levels increased in patients with drug-naïve metabolic syndrome compared to healthy controls?
Odds Ratio: 8.6 (95% CI 2.8–26.8)
p-value: p=<0.001
Full-length betatrophin concentrations are significantly elevated in drug-naïve patients with metabolic syndrome and correlate with fasting and 2-hour plasma glucose levels.
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Elevated betatrophin associates with metabolic syndrome; hypothesis-generating biomarker signal requiring prospective validation before clinical use.
Liu et al. (2017) conducted a case-control in Metabolic syndrome (n=94). Highest tertile of full-length betatrophin vs. Lower tertiles was evaluated on Metabolic syndrome (OR 8.6, 95% CI 2.8-26.8, p=<0.001). The highest tertile of full-length betatrophin levels was associated with significantly higher odds of having metabolic syndrome (OR 8.6; 95% CI 2.8-26.8; P<0.001).
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