The rotation technique is useful for structure determination of small animal viruses like foot-and-mouth disease virus, which resembles a 32-unit model.
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Rotation technique aids small-virus modeling; leaves open routine adoption pending higher-level confirmation.
With small, animal viruses for which electron-microscope images show little penetration by negative stain, the rotation technique for structure determination is useful. Foot-and-mouth disease virus resembles a 32-unit model when rotational images of virus and models simulating virus in negative stain are compared.
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Breese et al. (1965) studied this question.
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