Key result
Focal acidosis with 50% and 80% CO2 at multiple medullary raphe sites in awake goats increased inspiratory flow by 18.4% and 30.1%, respectively (P<0.05).
Population
Adult goats (n=7) with chronically implanted microtubules at two or three sites in the medullary raphe nuclei
Comparison
Focal acidosis created by microdialysis with… vs Microdialysis with mock CSF equilibrated with…
Design
Preclinical
Authors
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Focal raphe stimulation augments ventilation in awake goats; extends anesthetized models but leaves open human relevance.
p-value: p=<0.05
The large ventilatory response to global respiratory brain acidosis likely reflects the cumulative effect of stimulation at widespread chemoreceptor sites rather than a large stimulation at a single site.
Hodges et al. (2004) studied this question. Focal acidosis via microdialysis with 50% or 80% CO2 vs. Microdialysis with 6.4% CO2 (pH = 7.3) was evaluated on Inspiratory flow (p=<0.05). Focal acidosis with 50% and 80% CO2 at multiple medullary raphe sites in awake goats increased inspiratory flow by 18.4% and 30.1%, respectively (P<0.05).
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