Key result
Sodium nitroprusside and 8-Br-cGMP increased TREK-1 currents, an effect blocked by mutation of the PKG consensus sequence at serine 351.
TREK-1 encodes a stretch-activated potassium conductance in smooth muscles that is regulated by NO and cGMP-dependent protein kinase, potentially contributing to nitrergic inhibition.
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Supports PKG site S351 in TREK-1 activation; leaves open translation to human smooth muscle tone.
Koh et al. (2001) studied this question. Sodium nitroprusside and 8-Br-cGMP was evaluated on TREK-1 currents and open probability. Sodium nitroprusside and 8-Br-cGMP increased TREK-1 currents, an effect blocked by mutation of the PKG consensus sequence at serine 351.
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