What question did this study set out to answer?

To assess whether repeated administration of lansoprazole alters the single-dose pharmacokinetics and metabolic clearance of diazepam.

November 1, 1992Clinical Pharmacology & Therapeutics

Influence of lansoprazole treatment on diazepam plasma concentrations

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Authors

RLRomain A. LefebvreUniversité Claude Bernard Lyon 1 BFB FlouvatHôpital Ambroise-Paré SKSara Karolac-TamisierHôpital Ambroise-Paré

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Implication

Randomized double-blind crossover trial reveals no change in diazepam clearance or plasma levels in healthy volunteers, indicating lansoprazole does not impair diazepam metabolism.

Key Points

To assess whether repeated administration of lansoprazole alters the single-dose pharmacokinetics and metabolic clearance of diazepam.
Conducted a double-blind, randomized crossover trial in 12 healthy male volunteers receiving either 60 mg lansoprazole or placebo once daily for 10 days.
Administered 0.1 mg/kg diazepam intravenously on day 7, one hour after the oral study dose.
Collected serial blood samples up to 96 hours post-injection to quantify plasma concentrations of diazepam and its metabolite desmethyldiazepam.
In the placebo phase, diazepam elimination half-life was 26.0 ± 1.6 hours, clearance was 22.5 ± 1.1 ml/hr/kg, and volume of distribution was 0.82 ± 0.04 L/kg, with no significant differences observed during lansoprazole co-administration.
Plasma concentrations of the primary metabolite desmethyldiazepam remained unchanged between the lansoprazole and placebo regimens.

Cite This Study

Lefebvre et al. (1992) studied this question.

synapsesocial.com/papers/6a98da5fe8ca4d2af6362434 https://doi.org/10.1038/clpt.1992.172

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Implication

Randomized double-blind crossover trial reveals no change in diazepam clearance or plasma levels in healthy volunteers, indicating lansoprazole does not impair diazepam metabolism.

Influence of lansoprazole treatment on diazepam plasma concentrations

Discussion

Member takes

Implication

Key Points

Cite This Study

Influence of lansoprazole treatment on diazepam plasma concentrations

Discussion

Member takes

Implication

Key Points

Cite This Study

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