Key result
Human Parechovirus or Enterovirus infection was not associated with significant differences in motor development compared to uninfected peers at 24 months follow-up.
Why the study?
Little was known about the motor development of young Caucasian children after human Parechovirus or Enterovirus infections, as prior studies primarily evaluated Asian children with EV-71.
Does human Parechovirus or Enterovirus infection impair motor development in children at 24 months follow-up compared to uninfected peers?
Cohort (n=157)
Blinded
Yes
Does human Parechovirus or Enterovirus infection impair motor development in children at 24 months follow-up compared to uninfected peers?
HPeV or EV infection in childhood does not appear to significantly impair motor development at 24 months follow-up in a Western cohort.
Answers are grounded in this paper and cite their sources.
Reassures clinicians on motor outcomes at 24 months post-HPeV/EV; extends prior mostly Asian data to Caucasian children but leaves longer-term effects open.
BACKGROUND: Human Parechovirus (HPeV) and Enterovirus (EV) are known causes of viral infection and meningitis in childhood. Not much is known about the motor development of young Caucasian children after these infections. Most studies in the literature involved Asian children with only EV-71 infection, which is not prevalent in Western countries. METHODS: In this prospective multicenter blinded cohort study we tested the motor function level of children 24 months after an HPeV or EV infection (meningitis or elsewhere) and uninfected peers, with Bayley Scales of Infant Development -3 (BSID-3) and Movement Assessment Battery for Children-2 (M-ABC-2-NL). The total motor outcome, the fine motor function outcome and the gross motor function outcome were measured. Impaired motor development was defined as a z-score ≤-1. RESULTS: Of the 157 analyzed children, the total motor outcome was impaired in 16 (10%), the gross motor function was impaired in 26 (27%) and the fine motor function in 9 (6%) children. There was no significant difference between the outcome of children with a meningitis, an infection elsewhere and uninfected peers. In addition, no differences in motor development were found in a subgroup analysis after correcting for confounders, including age and gender. CONCLUSIONS: No significant differences in motor development were found between HPeV or EV infected and uninfected Dutch children after 24 months of follow-up.
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CROM et al. (2021) conducted a cohort in Human Parechovirus (HPeV) or Enterovirus (EV) infection (n=157). Human Parechovirus (HPeV) or Enterovirus (EV) infection vs. Uninfected peers was evaluated on Impaired motor development (z-score ≤-1). Human Parechovirus or Enterovirus infection was not associated with significant differences in motor development compared to uninfected peers at 24 months follow-up.
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