Key result
Granulocyte colony-stimulating factor (G-CSF) therapy reduced atherosclerotic lesion area in animal models compared with controls (WMD 7.29%; 95% CI 2.06-12.52%; P=0.006).
Why the study?
Does G-CSF therapy reduce atherosclerotic lesion area in animal models of atherosclerosis?
Meta-Analysis
Does G-CSF therapy reduce atherosclerotic lesion area in animal models of atherosclerosis?
Mean Difference: 7.29 (95% CI 2.06–12.52)
p-value: p=0.006
In a meta-analysis of animal models, G-CSF treatment significantly reduced atherosclerotic lesion area, suggesting a potential therapeutic role in atherosclerosis.
G-CSF reduces lesions in animal models; hypothesis-generating and leaves open human translation.
Background. Atherosclerosis is a common inflammatory disease. Stem cell and endothelial progenitor cell treatments can improve cardiac function after myocardial infarction. Granulocyte colony-stimulating factor (G-CSF) is a mobilisation agent, mobilising stem cells from the bone marrow to circulation in the blood. G-CSF may constitute a treatment of atherosclerosis. We have conducted meta-analysis to evaluate the current evidence for the effect of G-CSF on the progression of atherosclerosis in animal models and to provide reference for preclinical experiments and future human clinical trials of atherosclerosis treatment.Methods. We searched several databases and conducted a meta-analysis across seven articles using a random-effect model. All statistical analyses were performed using Review Manager Version 5.2 and Stata 12.0.Results. We found that G-CSF therapy was associated with reduced atherosclerotic lesion area (weighted mean difference (WMD): 7.29%; 95% confidence interval (CI): 2.06–12.52%; P=0.006 ). No significant differences in total serum cholesterol ( P=0.54 ) and triglyceride levels ( P=0.95 ) were noted in G-CSF treatment groups compared with controls. Multivariable metaregression analysis revealed that the animal type (rabbit, P=0.022 ) and frequency of G-CSF administration (>20, P=0.007 ) impacted the atherosclerotic lesion area changes.Conclusion. The meta-analysis suggested that G-CSF treatment might inhibit the progression of atherosclerosis in animal models.
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Liu et al. (2017) conducted a meta-analysis in Atherosclerosis. Granulocyte colony-stimulating factor (G-CSF) vs. controls was evaluated on Atherosclerotic lesion area (WMD 7.29%, 95% CI 2.06-12.52%, p=0.006). Granulocyte colony-stimulating factor (G-CSF) therapy reduced atherosclerotic lesion area in animal models compared with controls (WMD 7.29%; 95% CI 2.06-12.52%; P=0.006).
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