Key result
Mitral valve replacement was successfully performed in a 3-month-old infant with fungal endocarditis, but non-compliance with anticoagulation led to fatal prosthesis thrombosis one year later.
Case Report (n=1)
This case highlights the severe challenges and fatal consequences of non-compliance with anticoagulation therapy following mitral valve replacement in an infant.
Demands vigilant post-op surveillance after valve-sparing fungal endocarditis surgery in infants; leaves open optimal relapse-prevention strategies.
A three-month-old female infant with a structurally normal heart was diagnosed with fungal endocarditis of the mitral valve with cerebral embolism. After antifungal therapy and a valve-sparing operation with complete removal of the fungal vegetations, a relapse with complete destruction of the valve leaflets and severe mitral regurgitation with decompensated heart failure occurred three months later. A second operation with successful mitral valve replacement was performed. Non-compliance with the anticoagulant treatment with vitamin K antagonist led to thrombosis of the mitral valve prosthesis one year later, and the child died from acute pulmonary edema.
No takes yet. Share an insight, caveat, or question.
Vassileva et al. (2022) conducted a case report in Fungal endocarditis of the mitral valve (n=1). Mitral valve replacement was evaluated on Clinical course and survival. Mitral valve replacement was successfully performed in a 3-month-old infant with fungal endocarditis, but non-compliance with anticoagulation led to fatal prosthesis thrombosis one year later.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: