December 10, 2019Heart
Valve regurgitation in patients surviving endocarditis and the subsequent risk of heart failure
Key result
Moderate or severe left-sided valve regurgitation in infective endocarditis survivors was associated with a higher 5-year risk of heart failure (28.7% vs 12.4%; HR 3.53; 95% CI 1.72-7.25).
Why the study?
Significant valve regurgitation is common after native valve infective endocarditis, but the subsequent risk of heart failure after hospital discharge is sparsely described.
Does moderate or severe left-sided valve regurgitation increase the risk of heart failure in patients surviving medically treated infective endocarditis?
Study Design
Type
Cohort (n=192)
Structured PICO
Does moderate or severe left-sided valve regurgitation increase the risk of heart failure in patients surviving medically treated infective endocarditis?
P
Population
192 patients surviving native valve infective endocarditis treated medically and discharged alive, followed for 5 years.
E
Exposure
Moderate or severe left-sided valve regurgitation (aortic or mitral) assessed by echocardiography at IE discharge
C
Comparator
No valve regurgitation at IE discharge
O
Outcome
Longitudinal risk of heart failure (HF) at 5 years of follow-uphard clinical
Main Result
Hazard Ratio: 3.53 (95% CI 1.72–7.25)
Absolute Event Rate: 28.7% vs 12.4%
In patients surviving medically treated infective endocarditis, moderate or severe left-sided valve regurgitation at discharge is associated with a significantly higher risk of subsequent heart failure.
Authors
Discussion
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Implication
Moderate to severe regurgitation after medically treated IE warrants closer HF surveillance; leaves open whether intervention improves outcomes.
Cite This Study
Østergaard et al. (2019) conducted a cohort in native valve infective endocarditis (n=192). Moderate or severe left-sided valve regurgitation vs. No regurgitation was evaluated on Heart failure (HR 3.53, 95% CI 1.72 to 7.25). Moderate or severe left-sided valve regurgitation in infective endocarditis survivors was associated with a higher 5-year risk of heart failure (28.7% vs 12.4%; HR 3.53; 95% CI 1.72-7.25).