Key result
History of infective endocarditis was associated with higher long-term risks of ischemic stroke (aHR 1.59; 95% CI 1.40-1.80), hemorrhagic stroke, myocardial infarction, and heart failure.
Why the study?
Does a history of infective endocarditis increase the long-term risk of major adverse cardiac events compared to matched controls?
Population
10,116 survivors of infective endocarditis from the Taiwan National Health Insurance Research Database.
Comparison
History of infective endocarditis vs Propensity score-matched control subjects…
Design
Cohort
Authors
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May support enhanced long-term surveillance after infective endocarditis; leaves open whether targeted interventions reduce events.
Cohort (n=20,232)
Yes
Does a history of infective endocarditis increase the long-term risk of major adverse cardiac events compared to matched controls?
Hazard Ratio: 1.59 (95% CI 1.4–1.8)
Survivors of infective endocarditis remain at a substantially elevated long-term risk for major adverse cardiac events, including heart failure, stroke, and death, compared to matched controls.
Kuo et al. (2014) conducted a cohort in Infective Endocarditis (n=20,232). History of infective endocarditis vs. Matched control subjects without infective endocarditis was evaluated on Ischemic stroke (aHR 1.59, 95% CI 1.40-1.80). History of infective endocarditis was associated with higher long-term risks of ischemic stroke (aHR 1.59; 95% CI 1.40-1.80), hemorrhagic stroke, myocardial infarction, and heart failure.
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