Key result
Catheter-directed thrombolysis was associated with a significantly lower frequency of post-thrombotic syndrome at 1 year compared to superficial femoral vein ligation (6.7% vs 73.3%; p=0.0005).
Why the study?
The introduction of new treatments for deep vein thrombosis requires a detailed comparison of their effectiveness to prevent massive pulmonary thromboembolism and post-thrombotic syndrome.
Does catheter-directed thrombolysis reduce the frequency of post-thrombotic syndrome compared to superficial femoral vein ligation in patients with femoropopliteal thrombosis?
Cohort (n=30)
Yes
Does catheter-directed thrombolysis reduce the frequency of post-thrombotic syndrome compared to superficial femoral vein ligation in patients with femoropopliteal thrombosis?
Absolute Event Rate: 6.7% vs 73.3%
p-value: p=0.0005
Catheter-directed thrombolysis significantly reduces the incidence of post-thrombotic syndrome at 1 year compared to superficial femoral vein ligation in patients with femoropopliteal thrombosis.
May reduce post-thrombotic syndrome versus ligation; hypothesis-generating and requires randomized confirmation before practice change.
INTRODUCTION. The problem of preventing massive pulmonary thromboembolism and post-thrombotic syndrome in deep vein thrombosis has been studied for a long period. The introduction of new treatments for deep vein thrombosis requires a detailed comparison of their effectiveness. The OBJECTIVE of this work was a comparative analysis of ligation of the superficial femoral vein and regional thrombolytic therapy. MATERIAL AND METHODS. A retrospective multicenter study involving 30 patients with femoproplite thrombosis, who had received catheter-directed thrombolysis or ligation of the superficial femoral vein, was performed. The investigated patients underwent inpatient treatment. RESULTS. The data on the effectiveness of both methods in preventing pulmonary thromboembolism were obtained. When comparing both groups, we revealed a statistically significant difference in the frequency of the development of PTS and the severity of its development in 1 year after treatment. With ligation vein, 73.3 and 6.7% in the thrombolysis group (p=0.0005). CONCLUSION. Regional thrombolysis was an effective treatment for deep vein thrombosis and prevention of PTS. The authors declare no conflict of interest. The authors confirm that they respect the rights of the people participated in the study, including obtaining informed consent when it is necessary, and the rules of treatment of animals when they are used in the study. Author Guidelines contains the detailed information.
No takes yet. Share an insight, caveat, or question.
Bezlepkin et al. (2019) conducted a cohort in Femoropopliteal thrombosis (n=30). Catheter-directed thrombolysis vs. Ligation of the superficial femoral vein was evaluated on Development of post-thrombotic syndrome (PTS) at 1 year (p=0.0005). Catheter-directed thrombolysis was associated with a significantly lower frequency of post-thrombotic syndrome at 1 year compared to superficial femoral vein ligation (6.7% vs 73.3%; p=0.0005).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: