Key result
Catheter-directed thrombolysis cuts post-thrombotic syndrome ~68% versus anticoagulation alone.
Why the study?
Catheter-directed thrombolysis has emerged as an alternative to oral anticoagulation therapy for deep vein thrombosis treatment, but comparative efficacy and safety remain unclear.
Does catheter-directed thrombolysis reduce post-thrombotic syndrome in patients with deep vein thrombosis compared to anticoagulation only?
Comparison
Catheter-directed thrombolysis vs anticoagulation only
Design
Systematic review and meta-analysis of randomized controlled trials
Authors
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Supports CDT in acute DVT to prevent PTS; confirms RCT benefit and may inform guideline updates.
Meta-Analysis (n=1,005)
Does catheter-directed thrombolysis reduce post-thrombotic syndrome in patients with deep vein thrombosis compared to anticoagulation only?
Odds Ratio: 0.32 (95% CI 0.12–0.85)
Catheter-directed thrombolysis reduces the risk of post-thrombotic syndrome and improves iliofemoral vein patency compared to anticoagulation alone in patients with deep vein thrombosis.
Mastoris et al. (2019) conducted a meta-analysis in deep vein thrombosis (n=1,005). Catheter-directed thrombolysis vs. anticoagulation only was evaluated on overall post-thrombotic syndrome (OR 0.32, 95% CI 0.12-0.85). Catheter-directed thrombolysis reduced the odds of overall post-thrombotic syndrome compared to anticoagulation only (OR 0.32; 95% CI 0.12-0.85).
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