Key result
Catheter-directed thrombolysis reduces postthrombotic syndrome ~60% vs. anticoagulation alone but doubles major bleeding.
Why the study?
The comparative clinical outcomes of catheter-directed thrombolysis plus anticoagulation versus anticoagulation alone in proximal lower-extremity DVT were unclear.
Population
Patients with lower-extremity proximal deep vein thrombosis from 3 RCTs and 3 non-randomized studies
Comparison
Catheter-directed thrombolysis plus anticoagulation versus anticoagulation alone
Design
Meta-analysis of randomized controlled trials and non-randomized studies
Follow-up
6 months
Authors
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CDT may reduce postthrombotic syndrome and improve patency despite higher bleeding; extends mixed evidence but leaves hard-outcome benefits open.
Meta-Analysis
Odds Ratio: 0.4 (95% CI 0.19–0.96)
Zhang et al. (2015) conducted a meta-analysis in lower-extremity proximal deep vein thrombosis (DVT). Catheter-directed thrombolysis (CDT) plus anticoagulation vs. Anticoagulation alone was evaluated on postthrombotic syndrome (OR 0.4, 95% CI 0.19-0.96). Catheter-directed thrombolysis plus anticoagulation reduced postthrombotic syndrome (OR 0.4; 95% CI 0.19-0.96) but increased major bleeding (Peto OR 2.0; 95% CI 1.62-2.62) vs anticoagulation.
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