Key result
Serum LRP6 levels were non-significantly higher in patients with positive angiograms (0.175 ± 0.074 and 0.166 ± 0.063 ng/ml) compared to those with negative angiograms (0.160 ± 0.019 ng/ml).
Why the study?
Human lipoprotein receptor-related protein -6 (LRP6) plays a role in coronary artery disease development, but its serum levels across coronary angiogram findings and metabolic risk factors needed evaluation.
Does serum LRP6 level discriminate occluded coronary arteries in patients referred for coronary angiography?
Cross-Sectional (n=96)
Does serum LRP6 level discriminate occluded coronary arteries in patients referred for coronary angiography?
Answers are grounded in this paper and cite their sources.
Serum LRP6 levels may serve as a discriminator for the presence and extent of coronary artery occlusion in patients undergoing angiography.
Background: Human lipoprotein receptor-related protein -6 (LRP6) plays a role in the development of coronary artery disease. This study aimed to determine the serum level of the LRP6 in patients referred to the coronary angiogram taking into considerations the findings of coronary angiography, evidence of dyslipidemia, obesity and co-existed diabetes mellitus. Methods: This cross-sectional study included 96 patients who referred to coronary angiogram as an interventional diagnostic test for coronary artery disease. The patients were grouped into Group I (negative angiogram); Group IIA (non-obstructed coronary vessels, positive angiogram) and: Group IIB (obstructed coronary vessels, positive angiogram). The anthropometric measurement, blood pressure, and fasting serum lipid profile and glucose were determined. The serum levels of LRP6 were determined by using the Enzyme-Linked ImmunoSorbent Assay (ELISA). Results: A non-significant higher serum level of LRP6 observed in patients with a positive angiogram 0.175 ± 0.074 ng/ml (Group IIA) and 0.166 ± 0.063 ng/ml (Group IIB) compared with the negative angiogram (Group I: 0.160 ± 0.019 ng/ml). The area under the curve of LRP6 in patients with positive angiogram was significantly lower than that with a normal angiogram. Conclusion: We conclude that the serum level of LRP6 is a good discriminator of patients with coronary artery disease as the area under the curve of the serum levels of LRP6 is significantly decreased as the number of occluded coronary vessels increased.
No takes yet. Share an insight, caveat, or question.
Alhusseiny et al. (2019) conducted a cross-sectional in Coronary artery disease (n=96). Serum LRP6 levels vs. Negative angiogram (normal coronary arteries) was evaluated on Serum level of LRP6. Serum LRP6 levels were non-significantly higher in patients with positive angiograms (0.175 ± 0.074 and 0.166 ± 0.063 ng/ml) compared to those with negative angiograms (0.160 ± 0.019 ng/ml).
Synapse has enriched 10 related papers. Consider them for comparative context: