Key result
Elevated serum miRNA-346 marks acute coronary syndrome and weakly correlates with LRP6 protein levels.
Why the study?
Do serum miRNA-346 and LRP6 protein levels differ across patients with acute coronary syndrome, stable angina pectoris, and angiographically normal controls, and do they correlate with each other and with LDL-c?
Cross-Sectional (n=150)
No
Do serum miRNA-346 and LRP6 protein levels differ across patients with acute coronary syndrome, stable angina pectoris, and angiographically normal controls, and do they correlate with each other and with LDL-c?
Answers are grounded in this paper and cite their sources.
Circulating serum miRNA-346 is significantly elevated in patients with acute coronary syndrome and shows a weak independent positive association with LRP6 protein, whereas LRP6 protein moderately and inversely correlates with LDL-c.
MicroRNAs (miRNAs) function to silence target gene expression by repressing transcription or inducing mRNA degradation, thereby suppressing protein translation. Bioinformatics databases predict that the low-density lipoprotein receptor-related protein 6 gene ( LRP6 ) is a downstream target gene of human miRNA-346. LRP6 protein plays an important role in regulating low-density lipoprotein cholesterol (LDL-c) levels, and knockout of the LRP6 gene or reduced LRP6 protein activity is closely associated with hyperlipidemia and atherosclerosis. However, the relationship between circulating miR-346 and LRP6 protein levels in patients with coronary atherosclerotic heart disease (CAD) remains unclear. The present study aimed to investigate the expression levels of serum miR-346 and LRP6 protein in CAD patients and to evaluate the correlation between them. Patients who underwent coronary angiography for the first time at The First Affiliated Hospital of Chengdu Medical College between February 2023 and June 2023 were enrolled. Based on clinical presentation, they were divided into three groups: acute coronary syndrome (ACS, n = 52), stable angina pectoris (SAP, n = 58), and control ( n = 40). Serum miRNA-346, LRP6 protein, and LDL-c levels were compared among the groups, and correlations between these parameters and disease status were analyzed. Serum miRNA-346 levels in the ACS group were significantly higher than those in the SAP and control groups (H = 8.885, df = 2, P < 0.05). A weak but statistically significant positive correlation was observed between miR-346 and LRP6 protein levels ( r = 0.196, P < 0.05), which remained significant after multivariable adjustment for demographic and metabolic covariates. A moderate negative correlation was found between LRP6 protein and LDL-c levels ( r = − 0.530, P < 0.001). Serum miRNA-346 is involved in the pathological process of coronary atherosclerotic heart disease. A weak correlation exists between miRNA-346 and LRP6 protein levels.
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Hu et al. (2026) conducted a cross-sectional in Coronary atherosclerotic heart disease (acute coronary syndrome and stable angina pectoris) (n=150). Serum miRNA-346 and LRP6 protein expression levels in acute coronary syndrome vs. Stable angina pectoris (n=58) and angiographically normal controls (n=40) was evaluated on Serum miRNA-346 expression levels across groups and correlation with serum LRP6 protein levels (r = 0.196 (Spearman correlation between miRNA-346 and LRP6); H = 8.885 (across-group comparison of miRNA-346), p=0.012). Serum miRNA-346 levels were significantly higher in acute coronary syndrome than in stable angina or controls (P=0.012) and weakly correlated with LRP6 protein (r=0.196, P<0.05).
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