Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 1, 2016Birth Defects Research Part A Clinical and Molecular TeratologyOpen Access

Association between antibiotic use among pregnant women with urinary tract infections in the first trimester and birth defects, National Birth Defects Prevention Study 1997 to 2011

View Full Paper
Ask AI
Bookmark
Share

Authors

EAElizabeth C. AilesCenters for Disease Control and PreventionSGSuzanne M. GilboaCenters for Disease Control and PreventionSGSimerpal K. GillCenters for Disease Control and Prevention

Discussion

Loading...

Member takes

Implication

Case-control study observes elevated risks of specific birth defects with certain antibiotics in early pregnancy, indicating potential teratogenic effects.

Key Points

  • To examine associations between maternal antibiotic use and specific birth defects among women reporting periconceptional urinary tract infections, controlling for confounding by indication.
  • Population-based, multi-site case-control study (National Birth Defects Prevention Study) evaluating pregnancies from 1997 to 2011.
  • Included mothers of cases with over 30 major birth defects and controls without major birth defects who reported periconceptional urinary tract infections (one month pre-conception through month 3).
  • Estimated associations for nitrofurantoin, trimethoprim-sulfamethoxazole, and cephalosporins using penicillin users as the reference group.
  • Periconceptional urinary tract infections were reported by 7.8% (2,029/26,068) of case and 6.7% (686/10,198) of control mothers, with antibiotic use reported by 68.2% and 66.6%, respectively.
  • Among 608 case and 231 control mothers, nitrofurantoin was associated with oral clefts (aOR 1.97, 95% CI 1.10–3.53) compared to penicillin.
  • Trimethoprim-sulfamethoxazole was associated with esophageal atresia (aOR 5.31, 95% CI 1.39–20.24) and diaphragmatic hernia (aOR 5.09, 95% CI 1.20–21.69), while cephalosporins were associated with anorectal atresia/stenosis (aOR 5.01, 95% CI 1.34–18.76).

Cite This Study

Ailes et al. (2016) studied this question.

synapsesocial.com/papers/6a98e01bdea2d226f518e86chttps://doi.org/10.1002/bdra.23570
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Drugs in Pregnancy and Lactation. A Reference Guide to Fetal and Neonatal Risk.1983 · 854 citations
  2. 2Urinary tract infections in women: diagnosis and management in primary care2006 · 113 citations
  3. 3Screening for Asymptomatic Bacteriuria in Adults: U.S. Preventive Services Task Force Reaffirmation Recommendation Statement2008 · 88 citations
  4. 4Problems due to Small Samples and Sparse Data in Conditional Logistic Regression Analysis2000 · 373 citations
  5. 5Neonatal Outcomes After Gestational Exposure to Nitrofurantoin2013 · 60 citations