What question did this study set out to answer?

To identify risk factors associated with the recurrence of herpes simplex virus epithelial keratitis in patients receiving treatment for active stromal keratitis or iridocyclitis.

November 1, 1996British Journal of OphthalmologyOpen Access

Risk factors for herpes simplex virus epithelial keratitis recurring during treatment of stromal keratitis or iridocyclitis. Herpetic Eye Disease Study Group.

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Authors

KWKirk R. WilhelmusUniversity of North Carolina at Chapel Hill CDChandler R. DawsonStatens Serum Institut BBBruce BarronUniversity of North Carolina at Chapel Hill

Discussion

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Implication

Randomized trial uncovers risk factors for recurrent epithelial keratitis in stromal keratouveitis patients, highlighting the roles of past infection history and ethnicity.

Key Points

To identify risk factors associated with the recurrence of herpes simplex virus epithelial keratitis in patients receiving treatment for active stromal keratitis or iridocyclitis.
Evaluated 260 patients with active stromal keratitis and/or iridocyclitis without epithelial disease across three clinical trials in the Herpetic Eye Disease Study.
Administered a 10-week treatment regimen of topical placebo, topical prednisolone phosphate, or topical prednisolone phosphate with oral acyclovir, alongside topical trifluridine prophylaxis (4 times daily for 3 weeks, then twice daily for 7 weeks).
Monitored patients over a 16-week period for the occurrence of dendritic or geographic epithelial keratitis and trifluridine-related adverse effects.
HSV epithelial keratitis recurred in 12 (4.6%) patients, with no significant difference among treatment groups: 1 of 49 (2.0%) on topical placebo, 9 of 138 (6.5%) on topical corticosteroids alone, and 2 of 73 (2.7%) on corticosteroids plus oral acyclovir.
Univariate exponential models indicated that a history of prior HSV epithelial keratitis and non-white ethnicity were significantly associated with an increased risk of recurrence.
Adverse effects related to trifluridine prophylaxis included acute allergic blepharoconjunctivitis in 10 (3.8%) patients and corneal epithelial erosions in 11 (4.2%) patients.

Cite This Study

Wilhelmus et al. (1996) studied this question.

synapsesocial.com/papers/6a98e228e739824d2c78c01b https://doi.org/10.1136/bjo.80.11.969

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Implication

Randomized trial uncovers risk factors for recurrent epithelial keratitis in stromal keratouveitis patients, highlighting the roles of past infection history and ethnicity.

Risk factors for herpes simplex virus epithelial keratitis recurring during treatment of stromal keratitis or iridocyclitis. Herpetic Eye Disease Study Group.

Discussion

Member takes

Implication

Key Points

Cite This Study

Risk factors for herpes simplex virus epithelial keratitis recurring during treatment of stromal keratitis or iridocyclitis. Herpetic Eye Disease Study Group.

Discussion

Member takes

Implication

Key Points

Cite This Study

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