Why the study?
Does elevated myocardial extracellular potassium concentration enhance procainamide-induced rate-dependent conduction slowing in the intact canine heart?
Population
Intact canine heart model
Comparison
Procainamide at varying myocardial extracellular… vs Absence of procainamide at the same [K+]o and…
Design
Preclinical
Authors
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May increase procainamide proarrhythmic risk in hyperkalemia; leaves open translation from canine conduction data to patients.
Does elevated myocardial extracellular potassium concentration enhance procainamide-induced rate-dependent conduction slowing in the intact canine heart?
Elevated extracellular potassium enhances the rate-dependent conduction slowing induced by procainamide in vivo, highlighting a mechanism for altered drug efficacy or proarrhythmia in depolarized tissue.
Cascio et al. (1987) studied this question.
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