August 31, 2006Proceedings of the National Academy of SciencesOpen Access

Structure of an RNA switch that enforces stringent retroviral genomic RNA dimerization

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Key result

A 3D model of a retroviral RNA conformational switch illustrates how a two-step formation of an RNA tertiary structure yields a stringent molecular recognition event for genomic RNA dimerization.

Authors

CBChristopher S. BadorrekUnited States Department of Defense CGCostin M. GhergheUniversity of North Carolina at Chapel Hill KWKevin M. WeeksUniversity of North Carolina at Chapel Hill

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Implication

Hypothesis-generating for retroviral RNA mechanisms; leaves open any therapeutic translation to infected patients.

Key Points

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Cite This Study

Badorrek et al. (2006) studied this question. A 3D model of a retroviral RNA conformational switch illustrates how a two-step formation of an RNA tertiary structure yields a stringent molecular recognition event for genomic RNA dimerization.

synapsesocial.com/papers/6a98e3d62beb1e1a0778c2dd https://doi.org/10.1073/pnas.0606156103

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Structure of an RNA switch that enforces stringent retroviral genomic RNA dimerization

Discussion

Member takes

Implication

Key Points

Cite This Study

Structure of an RNA switch that enforces stringent retroviral genomic RNA dimerization

Discussion

Member takes

Implication

Key Points

Cite This Study

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