January 1, 1994Thrombosis and Haemostasis

Macroaggregation of Platelets in Plasma, as Distinct from Microaggregation in Whole Blood (and Plasma), as Determined Using Optical Aggregometry and Platelet Counting respectively, is Specifically Impaired following Cardiopulmonary Bypass in Man

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Why the study?

Does cardiopulmonary bypass impair platelet macroaggregation and microaggregation in patients?

Structured PICO

Does cardiopulmonary bypass impair platelet macroaggregation and microaggregation in patients?

Population

Patients undergoing cardiopulmonary bypass, including subgroups treated with aspirin or succinylated gelatin.

Intervention

Cardiopulmonary bypass

Comparator

Prebypass (baseline)

Outcome

Changes in platelet macroaggregation (assessed by optical aggregometry in platelet-rich plasma) and microaggregation (assessed by platelet counting in whole blood and platelet-rich plasma)surrogate

Cardiopulmonary bypass specifically impairs platelet macroaggregation, which may contribute to postoperative hemostatic defects.

Discussion

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Implication

Bypass selectively impairs macroaggregation, potentially contributing to bleeding; leaves open causal role and need for prospective validation.

Cite This Study

Menys et al. (1994) studied this question.

synapsesocial.com/papers/6a98e489174d19d294aefa34 https://doi.org/10.1055/s-0038-1648905

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Implication

Bypass selectively impairs macroaggregation, potentially contributing to bleeding; leaves open causal role and need for prospective validation.