Key result
Higher platelet-to-lymphocyte ratio was an independent predictor of in-hospital acute stent thrombosis in patients with non-ST elevated acute coronary syndromes (OR 1.008).
Why the study?
Acute stent thrombosis is a serious complication, and the study aimed to investigate the association of the novel inflammatory marker platelet-to-lymphocyte ratio with in-hospital acute stent thrombosis.
Does higher platelet-to-lymphocyte ratio predict in-hospital acute stent thrombosis in NSTEMI patients undergoing stent implantation?
Observational (n=1,300)
No
Does higher platelet-to-lymphocyte ratio predict in-hospital acute stent thrombosis in NSTEMI patients undergoing stent implantation?
Odds Ratio: 1.008 (95% CI 1.001–1.015)
p-value: p=0.018
Elevated platelet-to-lymphocyte ratio is an independent predictor of in-hospital acute stent thrombosis in patients with NSTEMI undergoing stent implantation.
Elevated PLR was associated with acute stent thrombosis after NSTEMI stenting; hypothesis-generating and requires prospective validation.
Aim:Cardiovascular diseases are the leading causes of mortality in the world. Interventional methods used in the treatment of coronary artery disease have revolutionized the treatment of the disease. Balloon angioplasty and coronary stenting are two miraculous treatment methods of the disease. Acute stent thrombosis(ST) is a serious and mortal complication of stent thrombosis. Platelet-to-lymphocyte ratio (PLR), a novel inflammatory marker, has previously been shown to be associated with cardiac problems. In this study, we aimed to investigate the association of PLR with in hospital acute stent thrombosis.Material and Methods: 1300 patients without ST elevated myocardial infarction (NSTEMI )who underwent stent implantation between January 2013 and December 2013 in our hospital were included in the study. Demographic, clinical, angiographic and laboratory parameters of all participants were recorded. Results:In the ST+ group hypertension, diabetes mellitus rates were higher, clopidogrel loading time was shorter. The mean PLR value was significantly higher in the ST+ group as compared to ST- group (133.3 ± 75.0 vs 110.1 ± 47.0, p= 0.005). In the multivariate analyses hypertension, diabetes mellitus, shorter clopidogrel loading time and PLR was found to be independent predictors of acute stent thrombosis.Conclusion:Our results demonstrated that PLR is an independent predictor of acute stent thrombosis in Non-ST elevated acute coronary syndrome patients.
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Karanfil et al. (2020) conducted an observational in Non-ST elevated acute coronary syndromes (n=1,300). Platelet-to-lymphocyte ratio vs. Lower platelet-to-lymphocyte ratio was evaluated on In-hospital acute stent thrombosis (OR 1.008, 95% CI 1.001-1.015, p=0.018). Higher platelet-to-lymphocyte ratio was an independent predictor of in-hospital acute stent thrombosis in patients with non-ST elevated acute coronary syndromes (OR 1.008).
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