Key result
Platelet-lymphocyte ratio levels were significantly elevated in patients with unstable angina pectoris compared to healthy controls (122.89 vs 104.21, p=0.005) and negatively correlated with Syntax score.
Why the study?
Platelet-lymphocyte ratio (PLR) has been introduced as a potential marker for thrombotic activity and inflammation, but its predictive value compared with the SXscore in patients with unstable angina pectoris in the emergency department needed investigation.
Does the Platelet-Lymphocyte Ratio (PLR) predict the severity of coronary lesions as assessed by the Syntax score in patients with Unstable Angina Pectoris?
Case-Control (n=152)
Double-blind
No
Does the Platelet-Lymphocyte Ratio (PLR) predict the severity of coronary lesions as assessed by the Syntax score in patients with Unstable Angina Pectoris?
Absolute Event Rate: 122.89% vs 104.21%
p-value: p=0.005
While the Platelet-Lymphocyte Ratio (PLR) is elevated in patients with unstable angina pectoris, it correlates negatively with the Syntax score, suggesting it is ineffective for evaluating the severity of coronary vascular damage in this population.
PLR elevation aids UAP identification in ED; challenges utility for lesion severity and leaves open prospective validation.
Department (ED). Platelet-lymphocyte ratio (PLR) has been introduced as a potential marker to determine excess thrombotic activity and inflammation in cardiac disorders. Syntax score (SXscore) is an anatomic scoring system based on coronary angiography that quantifies lesion severity and complexity and predicts poor cardiovascular outcomes, including mortality, in patients with ACS. This study aimed to investigate the predictive value of PLR compared with SXscore in patients with UAP in the ED.
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Bolatkale et al. (2021) conducted a case-control in Unstable Angina Pectoris (n=152). Platelet-lymphocyte ratio (PLR) vs. Healthy controls was evaluated on Mean Platelet-Lymphocyte Ratio (PLR) (p=0.005). Platelet-lymphocyte ratio levels were significantly elevated in patients with unstable angina pectoris compared to healthy controls (122.89 vs 104.21, p=0.005) and negatively correlated with Syntax score.
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