Key result
High platelet to lymphocyte ratio (>137) in patients with acute myocardial infarction undergoing primary PCI was associated with more no-reflow and higher in-hospital mortality.
Why the study?
Does a high platelet to lymphocyte ratio predict adverse outcomes in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention?
Observational (n=440)
Does a high platelet to lymphocyte ratio predict adverse outcomes in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention?
A high platelet to lymphocyte ratio is an independent predictor of no-reflow, higher Syntax scores, and in-hospital adverse events in patients with AMI undergoing primary PCI.
Answers are grounded in this paper and cite their sources.
PLR should not yet guide risk stratification in AMI; leaves open its prognostic value pending prospective validation.
We assessed the prognostic value of the platelet to lymphocyte ratio (PLR) in primary percutaneous coronary intervention (pPCI). Patients (n = 440) with acute myocardial infarction (AMI) who underwent pPCI were divided into 2 groups: low PLR (<137) and high PLR (>137). "Thrombolysis In Myocardial Infarction" (TIMI) flow grades and Syntax scores (SXS) were calculated from initial angiograms. In-hospital mortality rate and cardiac adverse events were obtained from medical records. Patients with high PLR had more no-reflow, higher SXS and higher mortality rate (p < 0.001, p < 0.001 and p = 0.008, respectively). In receiver operating characteristic curve analysis, high PLR predicted development of no-reflow (specificity 71% and sensitivity 85%), SXS>22 (specificity 52% and sensitivity 61%) and adverse events (specificity 67% and sensitivity 63%). In multivariate regression analysis, PLR was an independent risk factor for no-reflow, SXS>22 and in-hospital adverse events. In addition to PLR, we present the relationship between mean platelet volume, red cell distribution width and neutrophil to lymphocyte ratio and no-reflow, SXS and in-hospital adverse events.
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Ayça et al. (2014) conducted an observational in acute myocardial infarction (n=440). High platelet to lymphocyte ratio (>137) vs. Low platelet to lymphocyte ratio (<137) was evaluated on no-reflow, Syntax scores, and in-hospital mortality rate (p=<0.001 for no-reflow, 0.008 for mortality). High platelet to lymphocyte ratio (>137) in patients with acute myocardial infarction undergoing primary PCI was associated with more no-reflow and higher in-hospital mortality.
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