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February 8, 2017European Journal of Clinical Investigation

Pre-intervention platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio were positively correlated with TIMI frame count (R=0.372 and R=0.301, respectively; P<0.001) in STEMI patients.

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Why the study?

Do pre-intervention PLR and NLR correlate with post-PCI TIMI frame count in patients with STEMI?

Population

215 consecutive patients with ST-segment elevation myocardial infarction undergoing primary percutaneous…

Design

Cohort

Key result

Pre-intervention platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio were positively correlated with TIMI frame count (R=0.372 and R=0.301, respectively; P<0.001) in STEMI patients.

Authors

HVHossein VakiliMSMahin ShiraziMCMahsa Charkhkar

Discussion

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Member takes

Overview

May aid early no-reflow risk assessment in STEMI; hypothesis-generating observational data requiring prospective validation.

Study Design

Type

Observational (n=215)

Structured PICO

Do pre-intervention PLR and NLR correlate with post-PCI TIMI frame count in patients with STEMI?

P
Population
215 consecutive patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention.
E
Exposure
Pre-intervention assessment of platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR)
O
Outcome
Correlation with thrombolysis in myocardial infarction (TIMI) frame count and corrected TIMI frame count subsequent to primary PCIsurrogate

Main Result

Effect estimate: R: 0.372 for PLR, R: 0.301 for NLR

p-value: p=<0.001

Pre-intervention PLR and NLR are easily calculated indices that correlate with post-PCI TIMI frame count, potentially aiding in predicting the no-reflow phenomenon in STEMI patients.

Cite This Study

Vakili et al. (2017) conducted an observational in ST-segment elevation myocardial infarction (n=215). Platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) was evaluated on Thrombolysis in myocardial infarction (TIMI) frame count (R: 0.372 for PLR, R: 0.301 for NLR, p=<0.001). Pre-intervention platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio were positively correlated with TIMI frame count (R=0.372 and R=0.301, respectively; P<0.001) in STEMI patients.

synapsesocial.com/papers/6a98e4f552d74751e81ff27fhttps://doi.org/10.1111/eci.12736
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Utility of the Platelet–Lymphocyte Ratio for Predicting No Reflow in Patients With ST-Segment Elevation Myocardial Infarction2014 · 101 citations
  2. 2Platelet to lymphocyte ratio as a prognostic marker in primary percutaneous coronary intervention2014 · 49 citations
  3. 3Platelet/ lymphocyte ratio for prediction of no reflow phenomenon in ST elevation myocardial infarction managed with primary percutanous coronary intervention2020 · 7 citations
  4. 4Platelet‐Lymphocyte ratio is a predictor for the development of no‐reflow phenomenon in patients with ST‐segment elevation myocardial infarction after thrombus aspiration2021 · 15 citations
  5. 5The Utility the Platelet-to-Lymphocyte Ratio in Predicting Angiographic Reflow after Primary Percutaneous Coronary Intervention in Patients with Acute ST- Segment Elevation Myocardial Infarction2018