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January 1, 2019World Journal of Cardiovascular DiseasesOpen Access

Value of Platelet to Lymphocytes Ratio in Predicting Angiographic Reflow after Primary Percutaneous Coronary Intervention in STEMI Patient

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Key result

Pre-intervention platelet to lymphocyte ratio was significantly higher in STEMI patients who developed coronary no-reflow after primary PCI compared to those with normal reflow (139.65 vs 85.5, p<0.001).

Why the study?

No reflow after primary PCI increases morbidity and mortality, and the relation between admission platelet to lymphocyte ratio and angiographic reflow in STEMI needed assessment.

Does admission platelet to lymphocyte ratio predict angiographic no-reflow in STEMI patients undergoing primary PCI?

Population

Sixty STEMI patients eligible for primary PCI

Comparison

Post-intervention TIMI flow III vs TIMI flow 0, I, II

Design

Prospective study

Authors

AEAhmed EmaraNSNeveen I. SamyWFWalaa Farid

Discussion

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Member takes

Overview

May aid risk stratification in primary PCI; leaves open whether PLR-guided strategies improve outcomes.

Study Design

Type

Observational (n=60)

Multicenter

No

Structured PICO

Does admission platelet to lymphocyte ratio predict angiographic no-reflow in STEMI patients undergoing primary PCI?

P
Population
60 patients with acute ST-elevation myocardial infarction eligible for primary percutaneous coronary intervention within 12 hours of symptom onset.
E
Exposure
Pre-intervention platelet to lymphocyte ratio (PLR) assessment
C
Comparator
Normal reflow (post-intervention TIMI flow III) vs. No reflow (post-intervention TIMI flow 0, I, II)
O
Outcome
Angiographic reflow assessed by post-intervention TIMI flow gradesurrogate

Main Result

Absolute Event Rate: 139.65% vs 85.5%

p-value: p=<0.001

Pre-intervention platelet to lymphocyte ratio is an independent predictor of angiographic slow flow or no-reflow in patients with STEMI undergoing primary PCI.

Limitations

  • Sample size was limited by facility and supplies in the catheter laboratory

Cite This Study

Emara et al. (2019) conducted an observational in ST-elevation myocardial infarction (STEMI) (n=60). Platelet to lymphocyte ratio (PLR) vs. Normal reflow (TIMI III) was evaluated on Admission platelet to lymphocyte ratio (PLR) (p=<0.001). Pre-intervention platelet to lymphocyte ratio was significantly higher in STEMI patients who developed coronary no-reflow after primary PCI compared to those with normal reflow (139.65 vs 85.5, p<0.001).

synapsesocial.com/papers/6a98e4f552d74751e81ff27dhttps://doi.org/10.4236/wjcd.2019.94026
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Predictors of No-Reflow Phenomenon in Young Patients With Acute ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention2015 · 52 citations
  2. 2Clinical and procedural predictors of no-reflow in patients with acute myocardial infarction after primary percutaneous coronary intervention2014 · 79 citations
  3. 3Angiographic no-reflow phenomenon as a predictor of adverse long-term outcome in patients treated with percutaneous transluminal coronary angioplasty for first acute myocardial infarction2000 · 579 citations
  4. 4The Thrombolysis in Myocardial Infarction (TIMI) Trial1985 · 3,191 citations
  5. 5Combination Therapy With Abciximab Reduces Angiographically Evident Thrombus in Acute Myocardial Infarction2001 · 494 citations