Key result
Various surrogate measures, including flow-mediated dilatation, pulse wave velocity, and biomarkers, are commonly used to estimate arterial health during short-term dietary intervention trials.
This review provides a comprehensive overview of surrogate vascular function measures used in dietary trials, emphasizing the need to understand their physiological basis and limitations.
Surrogate arterial measures warrant cautious interpretation in dietary trials; leaves open their link to clinical outcomes.
The potential to reduce cardiovascular morbidity through dietary modification remains an area of intense clinical and scientific interest. Any putatively beneficial intervention should be tested within a randomised controlled trial which records appropriate endpoints, ideally incident CVD and death. However, the large sample sizes required for these endpoints and associated high costs mean that the majority of dietary intervention research is conducted over short periods among either healthy volunteers or those at only slightly increased risk, with investigators using a diverse range of surrogate measures to estimate arterial health in these studies. The present review identifies commonly employed techniques, discusses the relative merits of each and highlights emerging approaches.
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McCall et al. (2011) conducted a review in Vascular function. Dietary interventions was evaluated. Various surrogate measures, including flow-mediated dilatation, pulse wave velocity, and biomarkers, are commonly used to estimate arterial health during short-term dietary intervention trials.
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