Key result
Higher monocyte-to-HDL-cholesterol ratio was independently associated with the presence of ascending aorta dilatation in patients with bicuspid aortic valve (OR 1.048).
Why the study?
Ascending aortic dilatation is a common complication in bicuspid aortic valve, and the relationship between monocyte count-to-HDL-cholesterol ratio and aortic dilatation in these patients was investigated.
Cross-Sectional (n=347)
No
An elevated monocyte-to-HDL-cholesterol ratio is independently associated with ascending aorta dilatation in patients with bicuspid aortic valves, suggesting its potential utility as a simple biomarker for risk stratification.
MHR may flag aortic dilatation risk in bicuspid aortic valve; leaves open clinical utility pending prospective validation.
BACKGROUND: The importance of monocyte count-to-HDL-cholesterol ratio (MHR) in cardio- vascular diseases has been shown in various studies. Ascending aortic dilatation (AAD) is a common complication in the patients with bicuspid aortic valve. In this study, we aimed to investigate the relationship between MHR and the presence of aortic dilatation in the patients with bicuspid aortic valve. METHODS: The study population included totally 347 patients with bicuspid aortic valve.169 patients with aortic dilatation (ascending aorta diameter ≥ 4.0 cm) and 178 patients with no aortic dilatation. Echocardiographic and laboratory measurement was done and compared between groups. RESULTS: The mean age of the participants was 44.7 ± 15.4 years and average ascending aorta diameter was 3.2 ± 0.3 cm in dilatation negative group and 4.4 ± 0.4 cm in positive group. MHR was significantly increased in in patients with aortic dilatation. MHR and uric acid level was independently associated with the presence of aortic dilatation in the patients with bicuspid aortic valve. CONCLUSION: We found a significant relationship between MHR and aortic dilatation in the patients with bicuspid aortic valve.
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Açar et al. (2021) conducted a cross-sectional in Bicuspid Aortic Valve with or without Ascending Aorta Dilatation (n=347). Monocyte-to-HDL-cholesterol ratio (MHR) vs. Lower MHR was evaluated on Presence of ascending aorta dilatation (≥ 4.0 cm) (OR 1.048, 95% CI 1.003-1.095, p=0.037). Higher monocyte-to-HDL-cholesterol ratio was independently associated with the presence of ascending aorta dilatation in patients with bicuspid aortic valve (OR 1.048).
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