Key result
Higher monocyte/HDL cholesterol ratio is linked to greater aortic stiffness and lower distensibility.
Why the study?
Monocyte to high density lipoprotein cholesterol ratio (MHR) is a candidate marker of inflammation and oxidative stress, but its association with aortic elastic properties in hypertensive patients was unclear.
Is the monocyte to high-density lipoprotein cholesterol ratio (MHR) associated with impaired aortic elasticity in newly-diagnosed untreated hypertensive patients?
Observational (n=185)
Is the monocyte to high-density lipoprotein cholesterol ratio (MHR) associated with impaired aortic elasticity in newly-diagnosed untreated hypertensive patients?
In newly-diagnosed untreated essential hypertension, a higher monocyte to HDL cholesterol ratio is an independent predictor of impaired aortic elasticity.
MHR should not guide hypertension management; hypothesis-generating for aortic elasticity in cross-sectional data.
BACKGROUND: Monocyte to high density lipoprotein cholesterol ratio (MHR) is generally understood to be a candidate marker of inflammation and oxidative stress. Therefore, we aimed to assess the association between MHR and aortic elastic properties in hypertensive patients. METHODS: A total of 114 newly-diagnosed untreated patients with hypertension and 71 healthy subjects were enrolled. Aortic stiffness index, aortic strain and aortic distensibility were measured by using echocardiography. RESULTS: Patients with hypertension had a significantly higher MHR compared to the control group (p < 0.001). Also, aortic stiffness index (p < 0.001) was significantly higher and aortic distensibility (p < 0.001) was lower in the hypertensive group. There was a positive correlation of MHR with aortic stiffness index (r = 0.294, p < 0.001) and negative correlation with aortic distensibility (r = -0.281, p < 0.001). In addition, MHR and high sensitivity C-reactive protein have a positive correlation (r = 0.30, p < 0.001). Furthermore, MHR was found to be an independent predictor of aortic distensibility and aortic stiffness index. CONCLUSIONS: In patients with newly-diagnosed untreated essential hypertension, higher MHR was significantly associated with impaired aortic elastic properties.
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Yayla et al. (2017) conducted an observational in Hypertension (n=185). Monocyte/High-Density Lipoprotein Cholesterol Ratio (MHR) vs. Healthy subjects was evaluated on Aortic elastic properties (aortic stiffness index and aortic distensibility) (r = 0.294, p=< 0.001). Higher monocyte/HDL cholesterol ratio (MHR) was significantly associated with higher aortic stiffness index (r=0.294, p<0.001) and lower aortic distensibility (r=-0.281, p<0.001).
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