Key result
Higher monocyte-to-HDL ratio is linked to greater arterial stiffness in type 2 diabetes.
Why the study?
Chronic inflammation in diabetes promotes arterial stiffness, and MHR is linked to inflammation, but little is known about the relationship between MHR and arterial stiffness.
Cross-Sectional (n=81)
No
Effect estimate: β 0.361 (95% CI 0.023-0.093)
p-value: p=0.001
In patients with type 2 diabetes, a higher monocyte-to-HDL ratio is independently associated with increased arterial stiffness as measured by the Cardio Ankle Vascular Index.
MHR may flag stiffness risk in type 2 diabetes; hypothesis-generating and requires prospective validation before clinical use.
BACKGROUND: Previous studies proposed that chronic inflammation in diabetes has a role in abnormal collagen production and elastin degradation, which promotes arterial stiffness. Monocyte-to-High Density Lipoprotein cholesterol ratio (MHR) is a simple measurement associated with inflammation and oxidative stress. However, little is known about the relationship of MHR with arterial stiffness. This study aimed to determine the association of MHR with arterial stiffness in patients with diabetes. METHODS: A total of 81 patients with type 2 diabetes mellitus were enrolled in a cross-sectional study. Arterial stiffness factor in this study was Cardio Ankle Vascular Index (CAVI). We analyzed complete blood count and lipid profile in all participants, then performed statistical analysis to determine the relationship between MHR and CAVI. Receiver operating characteristic (ROC) analysis was used to estimate the cut-off values of MHR to predict CAVI ≥ 9. RESULTS: Median of MHR in this study was 11.91 with the mean of CAVI was 8.13 ± 0.93. Spearman correlation analysis revealed a significant positive correlation between MHR and CAVI (ρ = 0.239, p = 0.031). Multivariate analysis showed the independent association of MHR to arterial stiffness (β = 0.361, 95% CI 0.023-0.093) and to CAVI ≥ 9 (OR 1.181, 95% CI 1.047-1.332). The cut-off values of MHR for predicting CAVI ≥ 9 were identified as ≥ 13 (OR 3.289, 95% CI 1.036-10.441). CONCLUSION: MHR is associated with CAVI in patients with diabetes, irrespective of various potential confounders.
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Mayasari et al. (2021) conducted a cross-sectional in Type 2 diabetes mellitus (n=81). Monocyte-to-High Density Lipoprotein ratio (MHR) was evaluated on Arterial stiffness measured by Cardio Ankle Vascular Index (CAVI) (β 0.361, 95% CI 0.023-0.093, p=0.001). Monocyte-to-high density lipoprotein ratio was independently associated with arterial stiffness (β 0.361) in patients with type 2 diabetes.
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