Key result
Higher monocyte-to-HDL ratio linked to ~23% greater risk of elevated CIMT in diabetic retinopathy.
Why the study?
Cardiovascular disease incidence is increasing in diabetic retinopathy, but the relationship between carotid intima media thickness and the novel marker monocyte to HDL ratio in these patients without apparent cardiovascular disease was unknown.
Does the Monocyte to HDL ratio (MHR) correlate with carotid intima media thickness (CIMT) in diabetic retinopathy patients without apparent cardiovascular disease?
Cross-Sectional (n=141)
No
Does the Monocyte to HDL ratio (MHR) correlate with carotid intima media thickness (CIMT) in diabetic retinopathy patients without apparent cardiovascular disease?
Odds Ratio: 1.229 (95% CI 1.004–1.505)
p-value: p=0.046
High levels of Monocyte to HDL ratio (MHR) may serve as a simple, non-invasive marker for early detection of subclinical atherosclerosis in patients with proliferative diabetic retinopathy.
MHR-CIMT link in DR may flag subclinical risk; hypothesis-generating, needs prospective validation before any clinical use.
ABSTRACTAim: Incidence of cardiovascular diseases is gradually increasing in patients with diabetic retinopathy (DR). MHR (Monocyte/HDL ratio), is a novel marker related with cardiovascular and cerebrovascular diseases. The aim of this study was to investigate the relationship between a subclinical atherosclerosis marker, carotid intima media thickness (CIMT), and MHR in diabetic retinopathy patients without an apparent cardiovascular disease. Material and Method: 106 diabetic patients without an apparent cardiovascular disease and 35 healthy controls matched for age, gender and body mass index (BMI) were included in this study. The patients were separeted into four groups which were proliferative diabetic retinopahy (PDR , n=30), nonproliferative diabetic retinopathy (NPDR, n=35), diabetic patients without retinopathy (n=41) and control group (n=35). Anthropometric, biochemical parameteres and CIMT were measured. Correlation and regression analysis were done to assess the relation between MHR and CIMT. Results: MHR was significantly different between groups and significantly higher in PDR group (p < .001). CIMT, a marker for atherosclerosis, significantly differed between groups (p < .001). CIMT levels were significantly higher in PDR while similar values were found in other than groups. In PDR group, a significant correlation was found between MHR and CIMT ( r=0.96; p < .001). According to binary logistic regression analysis, MHR had a significant effect on CIMT [ β=0.206, (%95 CI : 1.004-1.505), P=0.046 ]. Conclusion: This study showed that in patients with diabetic retinopathy, high levels of MHR which is a non-invasive, simple and inexpensive marker, might be useful for determination of subclinical cardiovascular risk. This study which is the first in literature that investigated the relation between MHR and CIMT in diabetic retinopathy might have a benefit on early detection of cardiac risk in diabetic patients without an apparent cardiovascular disease.
No takes yet. Share an insight, caveat, or question.
Kan et al. (2019) conducted a cross-sectional in Diabetic retinopathy (n=141). Monocyte to HDL ratio (MHR) vs. Lower MHR was evaluated on Carotid intima-media thickness (CIMT) above median (OR 1.229, 95% CI 1.004-1.505, p=0.046). Higher monocyte to HDL ratio was significantly associated with increased carotid intima-media thickness (OR 1.229), serving as a marker for subclinical atherosclerosis in diabetic retinopathy.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: