Key result
Elevated monocyte-to-HDL ratio linked to ~96% higher odds of type 2 diabetes.
Why the study?
Diabetes mellitus is a major risk factor for atherosclerosis, but the relationship between monocyte count to HDL ratio, carotid intima-media thickness, and type 2 diabetes mellitus required investigation.
Is there a relationship between type 2 diabetes mellitus, monocyte to HDL cholesterol ratio (MHR), and carotid intima-media thickness (CIMT)?
Case-Control (n=120)
No
Is there a relationship between type 2 diabetes mellitus, monocyte to HDL cholesterol ratio (MHR), and carotid intima-media thickness (CIMT)?
Odds Ratio: 1.956 (95% CI 1.426–2.202)
Absolute Event Rate: 8.7% vs 5.3%
p-value: p=<0.001
Monocyte to HDL cholesterol ratio (MHR) is significantly elevated in patients with type 2 diabetes and may serve as an easily calculated indicator of atherosclerosis.
MHR may link to CIMT in diabetes; leaves open its added value for CAD risk prediction pending validation.
Aim: Diyabetes mellitus (DM) is a majör risk factor for atheroscleros. Circulating monocyte count plays an important role for new atherosclerotic plaque development. Also, there is a strong inverse relationship between high density lipoprotein cholesterol (HDL) and atherosclerosis. monocyte count/HDL ratio (MHR) is a novel inflammatory marker for atheroscleros. Carotid intima-media thickness (CIMT) can predict the presence or absence of coronary artery disease (CAD). I aimed to investigate relationship between CIMT, MHR and type 2 DM Methods: A total of 120 patients were divided into two groups (with type2 DM group = 60, control group: 60). Baseline characteristics, laboratory parameters, MHR and CIMT were recorded and compared between groups. Results: The Diabetes group had considerable higher CIMT, MHR levels compared to the control (p<0.001,p<0,001 respectively ). Also, CIMT levels showed significant correlation with blood glucose level (r=0.474, p<0.001). On the contrary, HDL levels were higher in the control group (p=0.010).Conclusion: In conclusion, I found significantly higher MHR and CIMT in the diabetic group and thus I think MHR, which is an easily calculated index, can be used in the daily clinical practice as an indicator of atherosclerosis in Type 2 DM patients.
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Hakan Kaya (2018) conducted a case-control in Type 2 Diabetes Mellitus (n=120). Monocyte to HDL cholesterol ratio (MHR) vs. Healthy controls was evaluated on Association of MHR with Type 2 Diabetes (OR 1.956, 95% CI 1.426-2.202, p=<0.001). An elevated monocyte to HDL cholesterol ratio was significantly higher in patients with type 2 diabetes compared to healthy controls and served as an independent determinant of the disease (OR 1.956).
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