Population
Chinese hamster ovary (CHO) cells and rat basophilic leukaemia (RBL) cells expressing the TRP homologue bCCE1
Comparison
Expression of bCCE1 and internal dialysis of IP3 vs Parental CHO(-) cells
Design
Preclinical
Authors
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Hypothesis-generating for CCE1 as store-operated Ca2+ channel; leaves open cardiac relevance pending native-cell and in vivo studies.
Recombinant channels formed by CCE1 exhibit highly selective permeation of Ca2+, reflecting the phenotype of store-operated channels.
Warnat et al. (1999) studied this question.
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