September 1, 1996AJP Cell Physiology

High permeation of L-type Ca2+ channels at physiological Ca2+: homogeneity and dependence on the alpha 1-subunit

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Population

Rat pituitary GH3 cell line, rat aortic A7r5 cell line, and Chinese hamster ovary cells expressing smooth…

Design

Preclinical

Authors

MGMaik GollaschVascular Medicine CRC RiedKlinikum rechts der Isar MLM. Liebold

Discussion

Member takes

Implication

No immediate clinical implications from cell models; leaves open native tissue validation of alpha1-subunit Ca2+ permeation.

Structured PICO

Population

Rat pituitary GH3 cell line, rat aortic A7r5 cell line, and Chinese hamster ovary (CHO) cells expressing smooth muscle (Cb) Ca2+ channel alpha 1-subunits

Intervention

Measurement of unitary currents at varying Ba2+ and Ca2+ concentrations

Outcome

Single channel conductancessurrogate

L-type (C-class) channels exhibit homogeneous high Ca2+ permeation under physiological conditions, determined by the intrinsic properties of the pore-forming alpha 1-subunit.

Cite This Study

Gollasch et al. (1996) studied this question.

synapsesocial.com/papers/6a86f7ef48ef9afcd2a2527c https://doi.org/10.1152/ajpcell.1996.271.3.c842

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High permeation of L-type Ca2+ channels at physiological Ca2+: homogeneity and dependence on the alpha 1-subunit

Discussion

Member takes

Implication

Structured PICO

Cite This Study

High permeation of L-type Ca2+ channels at physiological Ca2+: homogeneity and dependence on the alpha 1-subunit

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider