December 16, 2002Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topicsOpen Access

Termination of reentry in an inhomogeneous ring of model cardiac cells

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Why the study?

Does off-circuit rapid electrical stimulation terminate anatomical reentry in an inhomogeneous ring of model cardiac cells?

Population

One-dimensional ring of model cardiac cells simulating anatomical reentry

Comparison

Off-circuit rapid electrical stimulation in the… vs Off-circuit rapid electrical stimulation in a…

Design

Preclinical

Authors

SSSitabhra SinhaUniversity of Canterbury DCDavid J. ChristiniSUNY Downstate Health Sciences University

Discussion

Member takes

Implication

Hypothesis-generating for off-circuit ATP in VT; leaves open whether inhomogeneities are required for reentry termination in vivo.

Structured PICO

Does off-circuit rapid electrical stimulation terminate anatomical reentry in an inhomogeneous ring of model cardiac cells?

Population

One-dimensional ring of model cardiac cells (Luo-Rudy I action potential model and modified Fitzhugh-Nagumo model) simulating anatomical reentry

Intervention

Off-circuit rapid electrical stimulation (antitachycardia pacing) in the presence of circuit inhomogeneities (zone of slow conduction)

Comparator

Off-circuit rapid electrical stimulation in a homogeneous reentry circuit

Outcome

Termination of reentrant waves (conduction block of the anterograde branch of the stimulated wave)

Computational modeling demonstrates that structural or electrophysiological inhomogeneities in the reentry circuit are required for successful termination of ventricular tachycardia by off-circuit antitachycardia pacing.

Limitations

Use of a 1D model
Assumption of the heart as a monodomain rather than a bidomain
Simulation of ischemic tissue solely through a higher degree of cellular uncoupling

Cite This Study

Sinha et al. (2002) studied this question.

synapsesocial.com/papers/6a98ed5e2d0bc910e975b838 https://doi.org/10.1103/physreve.66.061903

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Termination of reentry in an inhomogeneous ring of model cardiac cells

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Termination of reentry in an inhomogeneous ring of model cardiac cells

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider