Key result
In 1-D and 2-D cardiac media models, the existence of inhomogeneity in the reentry circuit was essential for successful pacing termination of tachycardia.
Why the study?
Does pacing terminate anatomical reentry in 1-D and 2-D excitable cardiac media models?
Does pacing terminate anatomical reentry in 1-D and 2-D excitable cardiac media models?
Inhomogeneity in the reentry circuit is essential for successful pacing termination of tachycardia in computational models, which may inform more effective pacing algorithms.
Inhomogeneity essential for model-based pacing termination; leaves open translation to clinical reentry algorithms.
Reentry around non-conducting ventricular scar tissue, which often causes lethal arrhythmias, is typically treated by rapid stimulation from an implantable defibrillator. However, the mechanisms of termination (success and failure) are poorly understood. To elucidate such mechanisms, we studied pacing of anatomical reentry in 1-D and 2-D excitable cardiac media models. Our results suggest that the existence of inhomogeneity in the reentry circuit is essential for pacing termination of tachycardia to be successful. Considering the role of such inhomogeneities may lead to more effective pacing algorithms.
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Sinha et al. (2005) studied Anatomical reentry and lethal arrhythmias. Pacing (rapid stimulation) was evaluated on Mechanisms of pacing termination (success and failure). In 1-D and 2-D cardiac media models, the existence of inhomogeneity in the reentry circuit was essential for successful pacing termination of tachycardia.
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