Key result
Ginsenoside Rg1 induces apoptosis and impairs early preimplantation and postimplantation development of mouse embryos both in vitro and in vivo.
Population
Mouse blastocysts and pregnant mice
Comparison
Ginsenoside Rg1 vs Untreated controls
Design
Preclinical
Follow-up
4 days (in vivo)
Authors
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May signal embryotoxicity risk with ginsenoside Rg1; leaves open human translation pending further study.
Ginsenoside Rg1 exerts hazardous effects on mouse embryonic development by triggering oxidative stress-mediated intrinsic apoptotic signaling.
Anggelia et al. (2017) studied Embryonic development. Ginsenoside Rg1 vs. Untreated controls was evaluated on Apoptosis and embryonic development (implantation rate, resorption, weight). Ginsenoside Rg1 induces apoptosis and impairs early preimplantation and postimplantation development of mouse embryos both in vitro and in vivo.
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