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January 1, 2020Evidence-based Complementary and Alternative MedicineOpen Access

Ginsenoside Rg1 induced apoptosis in breast cancer cells and orally inhibited DMBA-mediated tumor incidence in rats, preventing oxidative damage and modulating cancer-related gene expression.

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Population

MDA-MB-MD-231 cell lines and Sprague Dawley rats

Comparison

Oral ginsenoside Rg1 in DMBA-induced mammary gland carcinogenesis

Design

Preclinical in vitro and animal experimental study

Authors

YCYan ChuWZWentao ZhangGKG. Kanimozhi

Discussion

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Overview

Hypothesis-generating for ginsenoside Rg1 in triple-negative breast cancer; leaves open clinical translation.

Structured PICO

P
Population
Triple-negative breast cancer cell lines (MDA-MB-MD-231) and Sprague Dawley rats with 7,12-dimethylbenz (a) anthracene (DMBA; 20 mg/rat) induced mammary gland carcinogenesis
I
Intervention
Ginsenoside Rg1 (oral administration in rats)
O
Outcome
Cytotoxicity, apoptotic cell death, and tumor incidencesurrogate

Ginsenoside Rg1 demonstrates significant anticancer properties against triple-negative breast cancer in both in vitro and in vivo experimental models.

Cite This Study

Chu et al. (2020) studied this question.

synapsesocial.com/papers/6a72bfe775498292b70bb489https://doi.org/10.1155/2020/8886955
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Also Consider

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  3. 3Ginsenoside Rg1 ameliorates oxidative stress and myocardial apoptosis in streptozotocin-induced diabetic rats2015 · 66 citations
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  5. 5Ginsenoside Rg3 Prolongs Survival of the Orthotopic Hepatocellular Carcinoma Model by Inducing Apoptosis and Inhibiting Angiogenesis2019 · 29 citations