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Objective: To investigate signs of liver disease, and biochemical and immunological markers in blood donors with isolated GBV‐C/HGV viremia. Methods: Eighteen donors with isolated GBV‐C/HGV viremia were followed up 3–5 years after initial identification. Testing for GBV‐C/HGV RNA, GBV‐C/HGV‐E2 antibodies and a range of biochemical and immunological tests was performed. Thirteen donors consented to liver biopsy. Results: Twelve donors remained GBV‐C/HGV viremic at follow‐up. Five donors had developed E2 antibodies. Liver biopsies revealed mild portal inflammatory lesions in 6/11 individuals with persistent viremia, and steatosis in 10/13 biopsied donors. Conclusion: Steatosis and mild portal inflammatory lesions were found in liver biopsies from several blood donors with isolated GBV‐C/HGV viremia.
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Björkman et al. (2000) studied this question.
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