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January 1, 2011Journal of the Korean Society of HypertensionOpen Access

Bosentan treatment significantly decreased serum ACE concentrations (114.1 vs 190.7 U/L) and serum aldosterone levels on day 28 in rats with monocrotaline-induced pulmonary hypertension.

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Why the study?

Does bosentan reduce renin-angiotensin system activation (ACE, aldosterone) in monocrotaline-induced pulmonary hypertension rats?

Population

90 six-week-old male Sprague-Dawley rats weighing 200-250 g

Comparison

Bosentan 20 mg/kg/day administered by gavage… vs Monocrotaline 60 mg/kg subcutaneous injection…

Design

Preclinical

Follow-up

28 days

Key result

Bosentan treatment significantly decreased serum ACE concentrations (114.1 vs 190.7 U/L) and serum aldosterone levels on day 28 in rats with monocrotaline-induced pulmonary hypertension.

Authors

SKSung Jin KimJHJi HaeHLHae Ryun Lee

Discussion

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Overview

Extends preclinical evidence on bosentan in experimental PH; leaves open translation to human disease.

Structured PICO

Does bosentan reduce renin-angiotensin system activation (ACE, aldosterone) in monocrotaline-induced pulmonary hypertension rats?

P
Population
90 six-week-old male Sprague-Dawley rats with monocrotaline-induced pulmonary hypertension, treated and observed for up to 28 days.
I
Intervention
Bosentan 20 mg/kg/day administered by gavage twice a day for 28 days, following monocrotaline 60 mg/kg subcutaneous injection
C
Comparator
Monocrotaline 60 mg/kg subcutaneous injection alone (M group) and saline subcutaneous injection (Control group)
O
Outcome
Changes in plasma renin, serum aldosterone, ACE concentrations, ACE gene expressions, and protein contentssurrogate

Main Result

Absolute Event Rate: 114.1% vs 190.7%

p-value: p=<0.05

Bosentan treatment attenuates the activation of the renin-angiotensin system, specifically reducing serum aldosterone and ACE levels, in a rat model of monocrotaline-induced pulmonary hypertension.

Limitations

  • Blood tests for plasma renin, serum aldosterone, and ACE were only performed on day 28, requiring further evaluation at different time points.
  • Individual variations exist even among animals of the same age and species, necessitating follow-up studies with larger sample sizes.
  • Further studies on the effects of bosentan according to different doses are required.
  • Blood tests for renin, aldosterone, and ACE were only performed on day 28
  • Need for follow-up studies with different doses of bosentan
  • Individual differences among animals despite same age and strain

Cite This Study

Kim et al. (2011) studied Monocrotaline-induced pulmonary hypertension (n=90). Bosentan vs. Monocrotaline alone (M group) and saline control (C group) was evaluated on Serum ACE concentration on day 28 (p=<0.05). Bosentan treatment significantly decreased serum ACE concentrations (114.1 vs 190.7 U/L) and serum aldosterone levels on day 28 in rats with monocrotaline-induced pulmonary hypertension.

synapsesocial.com/papers/6a98f3cf4f4bbec9e275bc00https://doi.org/10.5646/jksh.2011.17.1.28
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Monocrotaline-Induced Pulmonary Arterial Hypertension and Bosentan Treatment in Rats: Focus on Plasma and Erythrocyte Parameters2022 · 9 citations
  2. 2Gene Expression of Endothelin-1 and Endothelin Receptor A on Monocrotaline-Induced Pulmonary Hypertension in Rats After Bosentan Treatment2010 · 24 citations
  3. 3Effect of endothelin receptor blockade on monocrotaline-induced pulmonary hypertension in rats2009 · 8 citations
  4. 4Endothelin-1 receptor blockade induces upregulation of renin-angiotensin-aldosterone system expression in terms of blood pressure regulation2010 · 6 citations
  5. 5Nonspecific endothelin-receptor antagonist blunts monocrotaline-induced pulmonary hypertension in rats1997 · 96 citations