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January 21, 2010Journal of the Renin-Angiotensin-Aldosterone SystemOpen Access

Endothelin-1 receptor blockade induces upregulation of renin-angiotensin-aldosterone system expression in terms of blood pressure regulation

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Why the study?

Does dual blockade of the RAAS and endothelin system improve blood pressure control compared to monotherapy in mice?

Population

25 male C57BL/6 mice, treated from ages 6 to 12 weeks.

Comparison

Bosentan, valsartan, or dual blockade with both… vs Placebo or monotherapy vs dual therapy.

Design

Preclinical

Follow-up

6 weeks

Authors

BYBo YangCentral South UniversityYCYundai ChenInterventional / Structural CardiologyTLTian-de LiSichuan University

Discussion

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Implication

Dual blockade may enhance BP lowering in animal models; leaves open translation to human hypertension and should not change practice.

Structured PICO

Does dual blockade of the RAAS and endothelin system improve blood pressure control compared to monotherapy in mice?

P
Population
25 male C57BL/6 mice, treated from ages 6 to 12 weeks.
I
Intervention
Bosentan (10 mg/kg/d), valsartan (10 mg/kg/d), or dual blockade with both (10 mg/kg/d each) administered from 6 to 12 weeks of age.
C
Comparator
Placebo (for the expression level experiment) or monotherapy vs dual therapy (for the blood pressure experiment).
O
Outcome
Expression levels of RAAS components (angiotensinogen, renin, ACE) and systolic blood pressure (SBP) at the end of 6 weeks of treatment.surrogate

Dual blockade of the RAAS and endothelin system provides superior blood pressure reduction in mice compared to monotherapy, likely due to compensatory RAAS upregulation during endothelin blockade.

Cite This Study

Yang et al. (2010) studied this question.

synapsesocial.com/papers/6a82c5b08757ed1e60134409https://doi.org/10.1177/1470320309358108
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Also Consider

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