What question did this study set out to answer?

To assess whether high-dose systemic human C-type natriuretic peptide (CNP) infusion affects systemic and pulmonary haemodynamics or modulates responses to angiotensin II in healthy men.

January 1, 1995Cardiovascular Research

Human C-type natriuretic peptide: effects on the haemodynamic and endocrine responses to angiotensin II

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Why the study?

Does human C-type natriuretic peptide infusion alter systemic and pulmonary haemodynamics or the renin-angiotensin system response to angiotensin II in normal male volunteers?

Population

8 normal male volunteers

Comparison

Human C-type natriuretic peptide infusion for 30… vs Placebo infusion for 30 minutes, followed by…

Design

Other

Follow-up

60 minutes per session

Authors

RCRobert I. CargillNHS Fife ASAllan D. StruthersHeart Failure & Transplant BLBrian J. LipworthUniversity of Dundee

Discussion

Member takes

Implication

No acute effects in healthy men warrant no practice change; leaves open CNP roles in disease states or other pathways.

Key Points

To assess whether high-dose systemic human C-type natriuretic peptide (CNP) infusion affects systemic and pulmonary haemodynamics or modulates responses to angiotensin II in healthy men.
Conducted a two-occasion crossover study in 8 healthy male volunteers who received either human CNP (10 pmol·kg⁻¹·min⁻¹) or placebo (5% dextrose) for 60 minutes.
Added a concomitant infusion of angiotensin II (6 ng·kg⁻¹·min⁻¹) from minutes 30 to 60 during both study days.
Measured systemic and pulmonary haemodynamic variables alongside renin-angiotensin-aldosterone markers at baseline (T0), after CNP/placebo alone (T30), and after angiotensin II co-infusion (T60).
Infusion of CNP alone for 30 minutes had no significant effect on systemic or pulmonary haemodynamics or baseline renin-angiotensin system activity relative to placebo.
Co-infusion of CNP did not attenuate angiotensin II-induced increases in mean systemic arterial pressure (mean change 26.6 [SEM 2.3] mm Hg with CNP vs 30.3 [3.6] mm Hg with placebo) or mean pulmonary artery pressure (11.7 [2.5] mm Hg vs 10.9 [1.0] mm Hg).
Angiotensin II-stimulated aldosterone secretion was unaffected by CNP, showing an increase of 219 (40) pmol·L⁻¹ during CNP co-infusion compared with 242 (40) pmol·L⁻¹ during placebo.

Structured PICO

Does human C-type natriuretic peptide infusion alter systemic and pulmonary haemodynamics or the renin-angiotensin system response to angiotensin II in normal male volunteers?

Population

8 normal male volunteers

Intervention

Human C-type natriuretic peptide (CNP) infusion (10 pmol.kg-1.min-1) for 30 minutes, followed by concomitant infusion of angiotensin II (6 ng.kg-1.min-1) for a further 30 minutes

Comparator

Placebo (5% dextrose) infusion for 30 minutes, followed by concomitant infusion of angiotensin II (6 ng.kg-1.min-1) for a further 30 minutes

Outcome

Systemic and pulmonary haemodynamic variables and the activity of the renin-angiotensin system (aldosterone concentration) at baseline, 30 minutes, and 60 minutessurrogate

High-dose systemic infusion of human C-type natriuretic peptide does not significantly alter systemic or pulmonary hemodynamics or the endocrine response to angiotensin II in healthy men.

Cite This Study

Cargill et al. (1995) studied this question.

synapsesocial.com/papers/6a98f3d04f4bbec9e275bc05 https://doi.org/10.1016/s0008-6363(96)88554-3

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Human C-type natriuretic peptide: effects on the haemodynamic and endocrine responses to angiotensin II

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Human C-type natriuretic peptide: effects on the haemodynamic and endocrine responses to angiotensin II

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Also Consider