Relative potencies of different anti-herpes agents in the topical treatment of cutaneous herpes simplex virus infection of athymic nude mice
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Discussion
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Implication
Comparative animal study reveals differential efficacy among topical antivirals against cutaneous herpes in mice, highlighting four potent agents for treating localized infections.
Key Points
- Compare the relative potencies of thirteen established anti-herpes compounds administered topically against cutaneous herpes simplex virus type 1 infection.
- Inoculated athymic nude (nu/nu) mice intracutaneously with herpes simplex virus type 1 (KOS strain).
- Applied thirteen established anti-herpes compounds topically at a 1% concentration in a water-soluble ointment.
- Assessed herpetic skin lesion development and associated mortality across treatment groups in a single assay system.
- Four compounds emerged as the most active agents: phosphonoacetic acid, E-5-(2-bromovinyl)-2'-deoxyuridine, acycloguanosine, and trisodium phosphonoformate.
- The top-performing agents reduced skin lesion severity and associated mortality compared to the other evaluated compounds, though numerical effect sizes and p-values were not reported.
Cite This Study
Descamps et al. (1979) studied this question.