Why the study?
Does the addition of long- or short-chain fatty acids suppress glucose utilization in isolated perfused fetal pig hearts?
Population
Isolated perfused fetal pig hearts (0.9 gestation)
Comparison
1.5 mM palmitate or 1.0 mM octanoate added to… vs Buffer containing 10 mM glucose and insulin…
Design
Preclinical
Authors
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Long-chain fatty acids inhibit fetal heart glucose transport; extends mechanistic insights but leaves open human neonatal translation.
Does the addition of long- or short-chain fatty acids suppress glucose utilization in isolated perfused fetal pig hearts?
In fetal pig hearts, long-chain fatty acids suppress glucose uptake likely via inhibition of glucose transport rather than phosphofructokinase inhibition.
Werner et al. (1983) studied this question.
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