Why the study?
Does epidural anaesthesia affect uteroplacental blood flow in women undergoing caesarean section?
Does epidural anaesthesia affect uteroplacental blood flow in women undergoing caesarean section?
Epidural anaesthesia with bupivacaine for caesarean section does not significantly alter uteroplacental blood flow.
Supports epidural safety for placental flow in caesarean; leaves open confirmation in larger randomized trials.
The uteroplacental blood flow was measured before and during epidural anaesthesia for caesarean section in 11 women. The blood flow was measured with dynamic placental scintigraphy. After an i.v. injection of indium-113m chloride, the gamma radiation over the placenta was recorded with a computer-linked scintillation camera. The uteroplacental blood flow could be calculated from the isotope accumulation curve. The anaesthesia was performed with bupivacaine plain 0.5%, 18-22 ml and a preload of a balanced electrolyte solution 10 ml/kg b.w. was given. The placental blood flow decreased in eight patients and increased in three with a median change of -21%, not being statistically significant. No correlation between maternal blood pressure and placental blood flow was found.
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Skjöldebrand et al. (1990) studied this question.
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