Key result
Consumption of Panax ginseng saponins suppressed the expected increase in body weight and plasma triacylglycerols in male mice fed a high-fat diet, likely via pancreatic lipase inhibition.
Why the study?
Does Panax ginseng saponin reduce weight gain and plasma triacylglycerols in male Balb/c mice fed a high-fat diet?
Does Panax ginseng saponin reduce weight gain and plasma triacylglycerols in male Balb/c mice fed a high-fat diet?
Panax ginseng saponins may exert anti-obesity and hypolipidemic effects by inhibiting pancreatic lipase activity.
Should not change clinical practice; hypothesis-generating for lipase inhibition in diet-induced obesity models.
Roots of the herb Panax ginseng are known to contain high levels of bioactive saponins. Here, we isolated saponins from ginseng root powder and studied their inhibitory effect on the absorption of dietary fat in male Balb/c mice. Consumption of ginseng saponins suppressed the expected increase in body weight and plasma triacylglycerols, following a high-fat diet and observed higher intake. Consumption of ginseng saponins had no effect on the concentration of the total plasma cholesterol in both chow and high-fat diets in mice. The mode by which saponins from ginseng inhibit lipid metabolism was assessed as the in vitro inhibition of pancreatic lipase. Ginseng saponin inhibited pancreatic lipase with an apparent IC50 value of 500 mug/mL. Our results suggest that the anti-obesity and hypolipidemic effects of Ginseng in high-fat diet-treated mice were attributed to the isolated saponin fraction. These metabolic effects of the ginseng saponins may be mediated by inhibition of pancreatic lipase activity.
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Karu et al. (2007) studied High-fat diet-induced weight gain. Panax ginseng saponins vs. High-fat diet without saponins was evaluated on Body weight and plasma triacylglycerols. Consumption of Panax ginseng saponins suppressed the expected increase in body weight and plasma triacylglycerols in male mice fed a high-fat diet, likely via pancreatic lipase inhibition.
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